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目的探讨米非司酮治疗输卵管异位妊娠的临床疗效。方法选择中山市博爱医院2009年1月到12月妇科收治的生命体征稳定,无明显内出血的输卵管异位妊娠患者62例,所有患者均口服米非司酮50mg,2次/d,5d为1疗程,用药1疗程后取静脉血查β-HCG和阴道B超,比较应用米非司酮治疗后有效组与无效组与B超显示的盆腔包块大小以及血β-HCG情况之间的关系,并观察其副反应。结果有效组B超显示盆腔包块消失或变小者43例,占95.6,无效组B超显示盆腔包块无变化甚至增大者为17例,占100,B超显示盆腔包块<3cm为51例,有效41例,占80.3,>3cm为11例,有效2例,占18.2,根据治疗前B超显示盆腔包块<3cm者效果优于>3cm者,有效组血β-HCG均下降,无效组血β-HCG升高者为15例,占88.2,血β-HCG<500mIU/ml治疗效果优于>500mIU/ml者,共6例发生副反应,发生率为9.7。结论米非司酮的治疗效果更为显著,经济方便,而且副反应轻微,是一种治疗异位妊娠的理想药物。
Objective To investigate the clinical efficacy of mifepristone in the treatment of tubal ectopic pregnancy. Methods Sixty-two patients with tubal ectopic pregnancy who were stable in gynecology admitted to the Pok Oi Hospital of Zhongshan City from January 2009 to December 2009 were enrolled in this study. All patients were given mifepristone 50 mg twice daily for 5 days Course of treatment, after taking a course of treatment of venous blood taken beta-HCG and vaginal B-ultrasound, the application of mifepristone treatment effective group and ineffective group and B ultrasound showed pelvic mass size and blood β-HCG relationship between the situation , And observe its side effects. Results The effective group B ultrasound showed pelvic mass disappeared or smaller in 43 cases, accounting for 95.6, invalid group B ultrasound showed no change or even pelvic mass in 17 cases, accounting for 100, B ultrasound showed pelvic masses <3cm 51 cases, effective in 41 cases, accounting for 80.3,> 3cm in 11 cases, effective in 2 cases, accounting for 18.2, according to pre-treatment B-pelvic mass <3cm were better than> 3cm, . In ineffective group, 15 cases (88.2%) had elevated serum β-HCG, and the effect of blood β-HCG <500mIU / ml was better than> 500mIU / ml. Conclusion Mifepristone treatment is more effective, economical and convenient, and the side effects are mild. It is an ideal medicine for the treatment of ectopic pregnancy.