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目的通过对新疆喀什地区伽师县夏普陶勒乡维吾尔族妇女子宫颈病变进行现况调查,了解该地区子宫颈病变情况及子宫颈癌患病率,达到对子宫颈癌高发地区的预防和早诊早治的目的。方法实际普查2573人,对全部人群进行问卷调查,妇科检查,对所有样本采用液基细胞学检查(TCT)、DNA定量分析和HPV DNA联合检测。对TBS分级ASC-H以上、DNA定量分析可见或可见大量DNA倍体异常细胞以及ASC-US合并HPV阳性者,进一步做子宫颈活检。结果子宫颈癌患病率622/10万,TCT、DNA定量分析和HPV DNA联合检测对子宫颈癌的检出率达到100%;TCT结合HPV DNA检测对CIN2以上病变检出的敏感性为88.88%,TCT结合DNA定量分析敏感性为96.25%,差异无统计学意义,且前者特异性更高。结论新疆喀什地区维族妇女子宫颈癌的患病率较高,且呈上升趋势;应高度重视新疆地区维族妇女子宫颈患病状况,采取长期有效的措施,降低子宫颈癌的患病率;普查方法的联合应用能够提高子宫颈癌及癌前病变的检出率,使有病变的妇女得到早诊早治,同时TCT结合HPV检测可做为新疆子宫颈癌普查的有效方法之一。
Objective To investigate the prevalence of cervical lesions in Uygur women in Shaputell Township, Jiashi County, Kashi Prefecture of Xinjiang, so as to understand the prevalence of cervical lesions and the prevalence of cervical cancer in the region and to achieve early prevention and treatment of cervical cancer The purpose of diagnosis and treatment. Methods The actual census of 2573 people, questionnaire survey of all the people, gynecological examination, all samples using liquid-based cytology (TCT), DNA quantitative analysis and HPV DNA combined detection. TBS grading ASC-H above, DNA quantitative analysis of visible or visible a large number of DNA ploidy abnormal cells and ASC-US combined with HPV-positive, further cervical biopsy. Results The prevalence of cervical cancer was 622/100 000. The detection rate of cervical cancer by TCT, DNA quantitative analysis and HPV DNA test was 100%. The sensitivity of TCT combined with HPV DNA test was 88.88 %, TCT combined with DNA quantitative analysis of 96.25% sensitivity, the difference was not statistically significant, and the former more specific. Conclusion The prevalence of cervical cancer among Uighur women in Kashgar area in Xinjiang is high and rising trend. Uighur women in Xinjiang should attach great importance to the prevalence of cervical disease and take long-term and effective measures to reduce the prevalence of cervical cancer. The combination of methods can improve the detection rate of cervical cancer and precancerous lesions, so that women with lesions get early diagnosis and treatment, while TCT combined with HPV testing can be used as an effective screening of cervical cancer in Xinjiang one of the ways.