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目的 :研究乳腺癌雌孕激素水平、雌孕激素受体及c erbB 2癌基因蛋白的表达情况及其临床意义。方法 :分别应用12 5I放射免疫组化ABC法研究了 82例乳腺癌和 6 8例乳腺良性病变患者血清雌孕激素水平以及病变组织雌孕激素受体、癌基因c erbB 2的表达。结果 :乳腺癌组的雌激素水平和癌基因c erbB 2的表达率明显高于良性病变组 ,雌激素水平与腋淋巴结状况呈明显正相关。ER、PR的表达与腋淋巴结状况关系不大 ,但与临床分期呈明显负相关 ,ER的阳性表达者 5年无瘤生存率明显高于复发或死亡者。癌基因c erbB 2的阳性表达率与临床分期及远期生存率呈显著正相关。结论 :雌孕激素水平高、癌基因c erbB 2的阳性表达是乳腺癌预后不良的指标 ,ER、PR的阳性表达是乳腺癌预后良好的指标 ,对乳腺癌的诊断治疗和预后判断具有重要的指导意义。
Objective: To study the estrogen and progesterone levels, estrogen and progesterone receptor and c erbB 2 oncogene protein expression in breast cancer and their clinical significance. METHODS: Serum levels of estrogen and progesterone in 82 cases of breast cancer and 68 cases of benign breast lesions, as well as the expression of estrogen and progesterone receptors and oncogene c erbB 2 in the lesions were studied by 12 5I radioimmunohistochemical ABC method. Results: The estrogen level in the breast cancer group and the expression rate of the oncogene c erbB 2 were significantly higher than those in the benign lesion group. Estrogen level was positively correlated with the axillary lymph node status. The expression of ER and PR was not related to the status of axillary lymph nodes, but was negatively correlated with the clinical stage. The 5-year disease-free survival rate of positive expression of ER was significantly higher than that of recurrence or death. The positive expression rate of oncogene c erbB 2 was positively correlated with clinical stage and long-term survival rate. Conclusion: The high levels of estrogen and progesterone and the positive expression of oncogene c erbB 2 are indicators of poor prognosis of breast cancer. The positive expression of ER and PR is a good indicator of breast cancer prognosis. It is important for the diagnosis, treatment and prognosis of breast cancer. Guiding significance.