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尿中氨苯砜(DDS)测定方法各异,周氏(临床皮肤科杂志,第14卷,第3期,1985)的改良方法,用国产的 a-萘胺代替进口试剂 N-甲萘基盐酸=氨基乙烯,以反应板(或小试管)代替纸片,可以克服原 Bratton—Marshall 纸片法敏感度低,失效快,产生假阳性等缺点。用改良试剂,价廉易得,能长期保存使用。但因其原理是尿中氨苯砜的游离芳香胺在酸性中与亚硝酸发生重氮化反应,再与偶合剂起反应生成紫红色化合物,故磺胺类药可产生假阳性反应。
Urine dapsone (DDS) determination of different ways, Zhou (Journal of Dermatology, Volume 14, No. 3, 1985) improved method, with a-naphthylamine instead of imported reagent N- methylnaphthyl Hydrochloride = aminoethylene, the reaction plate (or small test tube) instead of paper, can overcome the low sensitivity of the original Bratton-Marshall paper method, failure, resulting in false positive shortcomings. With improved reagents, cheap and easy to use, long-term preservation. However, the principle is that the free amines of dapsone in urine are diazotized with nitrite in the acid and react with the coupler to form purple compounds, so the sulfonamides can produce false positive reactions.