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目的:探讨血小板计数、活化及其炎症因子与儿童喘息性肺炎的相关性。方法:选择30例喘息性肺炎患儿和非喘息性肺炎患儿30例作为研究对象,分别为喘息组和非喘息组,同时选取同期健康儿童30例作为健康对照组,然后测定3组的血小板膜表面CD62p,刺激血浆P选择素和转换生长因子-β(TGF-β)的浓度,并进行对比分析。结果:喘息组的CD62p明显高于健康对照组,两组相比,差异有统计学意义(P<0.05);血浆进行胶原刺激前后,3组的血浆P选择素和TGF-β的浓度均明显升高,差异有统计学意义(P<0.05);同时,刺激后血浆P选择素和TGF-β的浓度从高到低依次为喘息组、非喘息组和健康对照组,3组之间相比,差异有统计学意义(P<0.05)。结论:血小板计数是判断儿童喘息性肺炎病情的重要指标,血小板及其炎症因子在儿童喘息性肺炎发病过程中扮演着促炎角色,临床现象表现为血小板活化增强,炎症因子呈现高表达。
Objective: To investigate the correlation between platelet count, activation and inflammatory cytokines and asthmatic pneumonia in children. Methods: Thirty children with asthmatic pneumonia and 30 children with non-asthmatic pneumonia were selected as the study object. They were asthmatic group and non-asthmatic group. Thirty healthy children of the same period were selected as healthy control group, and then three groups of platelets Membrane surface CD62p, stimulated plasma P-selectin and transforming growth factor-β (TGF-β) concentrations, and comparative analysis. Results: The level of CD62p in asthmatic group was significantly higher than that in healthy control group (P <0.05). The concentrations of plasma P-selectin and TGF-β in plasma were significantly increased before and after collagen stimulation (P <0.05). At the same time, the concentrations of plasma P-selectin and TGF-βin high-to-low asthmatic group were asthmatic group, non-asthmatic group and healthy control group after stimulation, The difference was statistically significant (P <0.05). Conclusion: Platelet count is an important index for judging the status of asthmatic pneumonia in children. Platelet and its inflammatory cytokines play a proinflammatory role in the pathogenesis of asthmatic pneumonia in children. The clinical manifestations include enhanced platelet activation and high expression of inflammatory cytokines.