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目的:探讨儿童孤独症与免疫系统的关系,为儿童孤独症病因学研究提供依据。方法:选取天津市4所启智学校及1所私立孤独症早教干预培训机构的孤独症儿童进行CABS、CARS、ABC量表的评定,运用酶联免疫吸附法检测血清IL-1β、IL-2R、IL-6、IL-8的水平,单因素分析血清白细胞介素与儿童孤独症的关系,相关分析孤独症儿童血清白细胞介素水平与行为特征的关系。结果:孤独症儿童血清IL-1β、IL-2R、IL-6、IL-8水平与正常参考值的差异有统计学意义(P<0.01),且高于正常参考值。孤独症儿童血清IL-1β、IL-2R、IL-6、IL-8水平与ABC量表中躯体运动项目得分呈正相关(P<0.05),与CARS量表得分相关性检验差异无统计学意义(P均>0.05)。结论:孤独症儿童可能存在免疫系统损伤,血清白细胞介素水平可能与孤独症儿童的躯体运动障碍有关。
Objective: To explore the relationship between children’s autism and the immune system, and to provide evidence for the etiological study of children with autism. Methods: CABS, CARS and ABC scales were assessed in 4 autistic children’s schools in Tianjin and 1 private autism early intervention training institution. Serum IL-1β and IL-2R levels were measured by enzyme-linked immunosorbent assay , IL-6 and IL-8 in children with autism. The relationship between serum interleukin and autism in children was analyzed by univariate analysis. The correlation between serum interleukin levels and behavioral characteristics was analyzed. Results: The levels of IL-1β, IL-2R, IL-6 and IL-8 in children with autism had statistical significance (P <0.01), which were higher than the normal reference values. The levels of IL-1β, IL-2R, IL-6 and IL-8 in children with autism had a positive correlation with the scores of physical activity in the ABC scale (P <0.05), and there was no significant difference between them (P> 0.05). Conclusion: Children with autism may have immune system damage, serum interleukin levels may be related to autistic children with somatic dyskinesia.