华法林(warfarin,WF,苄丙酮香豆素)是一个口服抗凝血药。众所周知,WF与保泰松、羟基保泰松、安妥明、消炎痛、甲灭酸、水杨酸盐类及磺胺甲基异H恶唑等药物合用时抗凝作用增强。过去的观点认为发生这种相互作用是这些药物能把WF从血浆蛋白结合部位置换出来,使WF游离浓度增加。现在看来这仅仅是使WF抗凝作用增强的一个次要原因。许多研究指出:一些药物如保泰松、西米替丁、 Warfarin (WF, warfarin) is an oral anticoagulant. As we all know, WF and phenylbutazone, phenylbutazone, clofibrate, indomethacin, mefenamic acid, salicylates and sulfamethoxazole and other drugs in combination with anticoagulant effect increased. In the past, this interaction was thought to be the result of these drugs displacing WF from the plasma protein binding site and increasing the free WF concentration. It now appears that this is only one of the secondary causes of the anticoagulant effect of WF. Many studies point out that some drugs such as phenylbutazone, cimetidine,