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目的探讨骨代谢生化指标在恶性肿瘤骨转移诊断中的应用价值。方法选取2010-09-2015-06收入朝阳市第二医院的130例恶性骨肿瘤住院患者,骨转移组68例,无骨转移组62例,采用ELISA测定两组uPYD、uDPD、sBAP和sBGP4项骨代谢生化指标并对比测定结果。结果骨转移组uPYD、uDPD、sBAP3项指标测定结果均低于无骨转移组,组间比较均存在明显统计学差异(P<0.05),sBGP测定结果组间比较不存在统计学差异(P>0.05);两组uDPD测定结果高于正常参考值比例最高。结论 uPYD、uDPD和sBAP骨代谢生化指标可作为恶性肿瘤骨转移诊断的重要依据,其中sBGP的灵敏度最高,值得在临床上推广。
Objective To investigate the value of biochemical markers of bone metabolism in the diagnosis of bone metastases of malignant tumors. Methods A total of 130 hospitalized patients with malignant bone tumor, 68 patients with bone metastasis and 62 patients without bone metastasis, were enrolled in the Second Hospital of Chaoyang from 2010-09-2015-06. The uPYD, uDPD, sBAP and sBGP4 Biochemical markers of bone metabolism and comparative measurement results. Results The results of uPYD, uDPD and sBAP3 in bone metastasis group were lower than that in non-bone metastasis group (P <0.05), there was no statistical difference between the two groups (P> 0.05). The highest proportion of uDPD in the two groups was higher than the normal reference value. Conclusion The biochemical markers of bone metabolism of uPYD, uDPD and sBAP can be used as an important basis for the diagnosis of bone metastases of malignant tumors, of which sBGP has the highest sensitivity and is worthy of clinical application.