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动脉粥样硬化常与骨质疏松症共存,进一步分析发现脂代谢指标与骨代谢指标有相关性,而且多数用于治疗骨质疏松症的药物同时对血脂有调节作用,所以推测脂代谢与骨代谢有相关性。其机制可能有:脂肪酸可以促进成骨细胞向脂肪细胞的转化及促进前破骨细胞向破骨细胞分化,调节骨髓间质细胞分化的转录因子及信号转导途径,脂代谢与骨代谢的遗传基因有相关性,高脂血症后骨髓内脂肪细胞增多增大压迫微血管使骨头供血明显减少等。
Atherosclerosis and osteoporosis often coexist, further analysis found that lipid metabolism indicators and bone metabolism indicators are related, and most of the drugs used to treat osteoporosis at the same time regulate blood lipids, it is speculated that lipid metabolism and bone Metabolism is related. The mechanism may include: fatty acids can promote the transformation of osteoblasts to adipocytes and promote the differentiation of pre-osteoclasts to osteoclasts, the transcription factors and signal transduction pathways that regulate the differentiation of bone marrow stromal cells, the inheritance of lipid metabolism and bone metabolism Genes are related to hyperlipidemia increased bone marrow adipocytes increased oppression of microvascular to significantly reduce bone blood supply and so on.