马凡综合征(Marfan syndrome,MFS)由法国儿科医生Antoine Marfan在1896年命名。他描述了一名5岁的女孩,其上肢、下肢、手指和足趾都不成比例的长且细,肌肉发育很差,脊柱有侧弯,建议定名为细长指。1902年Ackard提出用蜘蛛足样指命名;以后Borger等强调了眼部症状,特别是将晶状体脱位作为本病的特征;1912年Salle首先注意到心血管损害和本 Marfan syndrome (MFS) was named in 1896 by the French pediatrician Antoine Marfan. He described a 5-year-old girl with long and thin arms, legs, fingers and toes that were poorly muscled, had scoliosis and suggested slender fingers. In 1902, Ackard proposed to use the spider foot-like finger named; after Borger et al emphasized the ocular symptoms, especially the lens dislocation as the characteristics of the disease; Salle first noted in 1912 and cardiovascular damage