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抗酸剂即使不比甲氰咪胍更好,通常也是同样有效。如按照FDA规定,将甲氰咪胍用于十二指肠溃疡,它便是一个有效的药物。随着它被不加选择的用于如消化不良、疼痛、恶心和呕吐的症状,便产生了疑问。1976年11月～1979年2月在美国大约有1100万病人用过甲氰咪胍治疗,而在英国和欧洲,则更为众多。甲氰咪胍并不是一个万能药,它被普遍地过量使用着。在欧洲,650名病人的八组试验证明,甲氰咪胍对十二指肠溃疡病人临床上有效;美国一个大的多中心试验则得出相反的结果。
Antacids are usually equally effective, if not better than cimetidine. Cimetidine is a potent drug for duodenal ulcers if it is prescribed by the FDA. As it is indiscriminately used for symptoms such as indigestion, pain, nausea and vomiting, questions arise. From November 1976 to February 1979, about 11 million patients in the United States used cimetidine, and in Britain and Europe they were even more numerous. Cimetidine is not a panacea and it is generally overused. In Europe, eight trials of 650 patients demonstrated that cimetidine was clinically effective in patients with duodenal ulcer; a large multicentre trial in the United States had the opposite result.