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大鼠经~(60)Co-γ线800rad全身照射后1、2、4、7和10天,分别测定小肠粘膜γ-谷氨酰转移酶(γ-GT)、亮氨酸氨肽酶(LAP)和三磷酸腺苷酶(ATP酶)的活性以及对照组的酶活性。结果发现:LAP活性于第1天较对照组升高非常显著,第2天即显著下降,并持续下降至第7天。ATP酶活性于第2天上升非常显著,第7天稍有下降。γ-GT活性于第1、2天都升高非常显著,第4天即趋于正常水平。提示这三种膜酶对射线均敏感。照射后LAP活性显著下降且持续时间较长,可能是辐射引起小肠对氨基酸吸收障碍的机理之一。照射后ATP酶及γ-GT活性的变化与小肠对氨基酸吸收机能间的联系,尚待进一步研究。
Rats were sacrificed at 1, 2, 4, 7 and 10 days after irradiated with ~ (60) Co-γ ray at 800rad. The expressions of γ-glutamyl transferase (γ-GT), leucine aminopeptidase LAP) and adenosine triphosphate (ATPase) activity of the control group. The results showed that: LAP activity in the first day compared with the control group increased significantly, the first two days decreased significantly, and continued to decline until the seventh day. ATPase activity increased very significantly on the 2nd day and slightly decreased on the 7th day. γ-GT activity in the first two days were very significant increase, the first four days that tends to normal levels. These three kinds of membrane enzyme tips are sensitive to radiation. LAP activity decreased significantly after irradiation and lasts longer, which may be one of the mechanisms of radiation-induced intestinal absorption of amino acids. The relationship between the changes of ATPase and γ-GT activity and the function of intestinal absorption of amino acids after irradiation remains to be further studied.