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脾尔康是由白术、茯苓、山楂、陈皮等中药加氨基酸、硫酸锌、硫酸亚铁等组成的复方冲剂。本研究证明:脾尔康lg/kg或4g/kg×4d给小鼠灌胃,能显著促进小鼠免疫特异性玫瑰花结形成细胞,对抗免疫抑制剂环磷酰胺所致的细胞免疫功能低下和免疫器官胸腺、脾脏萎缩;脾尔康也能促进小鼠腹腔巨噬细胞的吞噬功能,并能对抗地塞米松引起的巨噬细胞吞噬功能降低,表明它具有增强特异性免疫和非特异性免疫功能的作用。脾尔康还能延长小鼠游泳、耐缺氧和耐高温时间,表明它具有抗应激作用。此外,它对慢性放血所致的大鼠缺铁性贫血有防治效果。小鼠灌胃给药急性毒性LD50=84.19±1.40g/kg。大鼠长期毒性试验证明,它对主要器官的功能和形态无明显影响。
Spleen Erkang is a compound granule consisting of Atractylodes macrocephala, Poria, hawthorn, tangerine peel, and other amino acids, zinc sulfate, and ferrous sulfate. This study proves that: spleen Erkang lg/kg or 4g/kg×4d gavage the mice, can significantly promote the immune-specific rosette formation cells in mice, against the immune inhibitor cyclophosphamide caused by cellular immune dysfunction And the immune organs thymus, spleen atrophy; spleen Erkang can also promote phagocytic function of mouse peritoneal macrophages, and can reduce phagocytic function caused by dexamethasone macrophages, indicating that it has enhanced specific immunity and non-specific immunity The function of the function. Splenicol also prolonged swimming, hypoxia tolerance and high temperature tolerance of mice, indicating that it has anti-stress effect. In addition, it has a preventive effect on chronic iron deficiency caused by iron deficiency anemia in rats. The mice were given intragastric administration acute toxicity LD50=84.19±1.40 g/kg. Long-term toxicity test in rats showed that it had no significant effect on the function and morphology of major organs.