目的评价米卡芬净治疗重症侵袭性真菌感染患者的疗效和安全性。方法采用回顾性分析2007年12月~2009年6月大连医科大学附属二院ICU病房40例侵袭性真菌感染患者应用米卡芬净治疗的临床资料。结果40例患者中,痊愈10例(25%),显效18例(45%),总有效率为70%,真菌清除率为60.8%,不良反应少,所有患者均耐受治疗。结论米卡芬净治疗重症侵袭性真菌感染安全、有效。 Objective To evaluate the efficacy and safety of micafungin in the treatment of patients with severe invasive fungal infection. Methods The clinical data of 40 patients with invasive fungal infection in ICU ward of Second Affiliated Hospital of Dalian Medical University from Dec 2007 to Jun 2009 were analyzed retrospectively. Results Among the 40 patients, 10 cases were cured (25%), 18 cases (45%) were cured, the total effective rate was 70%, fungal clearance rate was 60.8%, and adverse reactions were few. All patients were tolerated. Conclusion Micafungin treatment of severe invasive fungal infection is safe and effective.