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黄曲霉毒素(Aflatoxin简称AFT)是黄曲霉(Aspergillus Flavus)和寄生曲霉(A.Parasiticus)中产毒菌株的代谢产物。在自然界黄曲霉的分布较寄生曲霉普遍,所以主要产毒是黄曲霉。黄曲霉毒素的种类 1962年Nesbett等用氧化铝层析板法,在紫外线照射下,看到两种萤光,一种呈蓝色,取字首命名为B,名一种呈绿色,取字首命为G;1963年Hartey等发现于B、G下各有一个小萤光点,即命名为B_1、G_1和B_2、G_2;1966年Holzapfel等以B_1、B_2和G_1、G_2混合毒素喂羊,48小时后在尿中发现有蓝紫色和深紫色的萤光物质,定名为m_1、m_2;1971年亦报导“B_1”毒素在猴体内可转变为另一代谢产物“P_1”。到目前为止用色层分析法从分离的毒素中发现有20种萤光物质,已鉴定的有12种,包
Aflatoxin (AFT) is a metabolite of toxigenic strains of Aspergillus Flavus and A. parasiticus. In nature, the distribution of Aspergillus flavus is more common than that of parasitic Aspergillus, so the main producing virus is Aspergillus flavus. Aflatoxin types 1962 Nesbett and other alumina chromatography plate method, under ultraviolet light, see two kinds of fluorescence, a blue, take the first name is called B, the name of a green, take the word The first was G; in 1963, Hartey et al. Found a small fluorescent spot under B and G, named as B_1, G_1 and B_2, G_2. Holzapfel et al in 1966 fed sheep with B_1, B_2 and G_1, G_2 mixed toxins After 48 hours, blue and purple purples were found in the urine and named as m_1, m_2. In 1971, it was also reported that “B_1” toxin could be transformed into another metabolite “P_1” in the monkey. So far, 20 kinds of fluorescent substances have been found from the isolated toxins by chromatography, and 12 kinds have been identified