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本文研究了口服碱提类肝素组分Ⅰ对鹤鹑血清及动脉壁胆固醇的影响。雄性朝鲜鹤鹑14只,随机分成两组。皆喂高脂饮食(含1％胆固醇),其中一组给予碱提类肝素组分Ⅱ600mg/kg/d,灌胃,另一组作为对照组。于给药前及药后四、八周未禁食12小时后取血测血清Tc、HDL_2-c及DL_3-c,计算HDL_2-c、HDL-c/Tc、HDL_2-c/、HDL_3-c值。八周后断头处死动物,测动脉壁胆固醇含量。结果表明,口服碱提类肝素组分Ⅱ能提高鹤鹑血清HDL及其亚组分水平及HDL-c/Tc值对血清Tc、HDL_2-c/HDL_3-c值及动脉壁胆固醇无显著影响。碱提类肝素组分Ⅱ是碱提类肝素调整血脂的有效成分。实验表明,该药腹腔注射能抑制由高脂饮食所致的鹤鹑血清胆固醇的升高及HDL-c/Tc、HDL_2-c/HDL_3-c值的降低,并能减少胆固醇及其酯在动脉壁的沉积。本实验研究了口服碱提类肝素组分Ⅱ对上述指标的影响。
In this paper, we investigated the effect of oral alkali-containing heparin component I on serum and arterial wall cholesterol of hen. 14 male Korean quail, were randomly divided into two groups. All were fed a high-fat diet (including 1% cholesterol). One group was given alkali-loaded heparin componentⅡ600mg / kg / d, and the other group served as the control group. HDL-c, HDL-c / Tc, HDL-2 / c, HDL-3-c were measured before and 12 weeks after fasting for four or eight weeks. value. Eight weeks later the animals were decapitated and the arterial wall cholesterol content measured. The results showed that oral administration of heparin fraction Ⅱ could improve the levels of serum HDL and its sub-components and HDL-c / Tc in serum and had no significant effect on Tc, HDL_2-c / HDL_3-c and arterial wall cholesterol. Alkaline extraction of heparin component Ⅱ is an alkali-based heparin to adjust the effective components of blood lipids. Experiments show that the drug intraperitoneal injection can inhibit high-fat diet caused by elevated serum cholesterol and the HDL-c / Tc, HDL_2-c / HDL_3-c value decreased, and can reduce cholesterol and its esters in arteries Wall deposition. In this study, we investigated the effect of oral alkali-containing heparin component II on these indices.