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目的探讨凋亡抑制蛋白survivin和血管内皮生长因子(VEGF)在非小细胞肺癌(NSCLC)组织中的表达及与其预后的关系。方法应用免疫组化SP法,检测2000年1月至2003年12月承德医学院附属医院肿瘤内科收治的70例NSCLC患者(化疗组35例和非化疗组35例)肺癌组织及40例对照组患者癌旁组织中sur-vivin、VEGF的表达,比较survivin、VEGF的表达与NSCLC生存率的关系。结果survivin和VEGF在NSCLC中的阳性表达率分别为74.3%和70.0%,与对照组比较,差异均有显著性意义(P<0.01);并且二者呈正相关(P=0.032,r=0.527);化疗组中survivin、VEGF表达阳性者生存时间明显低于阴性表达者。结论survivin与VEGF在NSCLC组织中的表达呈正相关;二者联合检测对患者化疗疗效、预后的判断具有指导作用。
Objective To investigate the expression of survivin and vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC) and its relationship with prognosis. Methods Immunohistochemical SP method was used to detect lung cancer tissues in 70 patients with NSCLC (35 patients in chemotherapy group and 35 patients in non-chemotherapy group) and 40 patients in control group admitted to Department of Oncology, Chengde Medical College Hospital from January 2000 to December 2003. The expression of survivin and VEGF in paracancerous tissues and the relationship between the expression of survivin and VEGF and the survival rate of NSCLC were compared. Results The positive rates of survivin and VEGF in NSCLC were 74.3% and 70.0%, respectively, which were significantly different from those in the control group (P <0.01). There was a positive correlation between them (P = 0.032, r = 0.527) The survival time of survivin and VEGF in chemotherapy group was significantly lower than that in negative expression group. Conclusions There is a positive correlation between the expression of survivin and VEGF in NSCLC. The combined detection of them has a guiding role in judging the curative effect and prognosis of patients.