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目的：探讨经尿道前列腺电切术（transurethral resection of the prostate，TURP）后联合使用索利那新及坦索罗辛的临床疗效与安全性。方法收集我院116例行手术的前列腺增生症患者，随机分成两组，实验组院术后早期联合使用索利那新及坦索罗辛58例，对照组院术后单独使用坦索罗辛58例。比较两组术后安置尿管期间膀胱痉挛次数，术后2w膀胱过度活动症评分（overactive bladder syndrome score，OABSS）、尿流率和生活质量评分（quality of life，QOL）。结果联合用药组患者术后安置尿管期间膀胱痉挛次数明显低于对照组（<0.05）；术后2w左右联合用药组尿频、尿急次数明显低于对照组（0.05）。联合用药组患者均无明显药物不良反应，生活质量提高。结论早期联合应用索利那新及坦索罗辛是安全有效的，提高患者的生活质量，值得临床推广。“,”Objective To investigate the TURP after the combined use of solifenacin and tamsulosin in clinical efficacy and safety. Methods 116 patients were randomly divided into two groups,The experimental group: Early postoperative combined use of solifenacin and tamsulosin in 58 cases, The control group: After separate use of tamsulosin 58 cases. Comparison of the two groups after the placement of catheter during times of bladder spasm, 2 weeks after the operation, OABSS, urine flow rate and QOL. Results Joint patients after placement of the catheter treatment group during times of bladder spasm was significantly lower than the control group ( <0.05);2 weeks in combination group frequent micturition, urgency frequency were significantly lower than those in control group ( 0.05).Conclusion Early application of solifenacin and tamsulosin is safe and effective, can improve the quality of life of patients, is worthy of clinical promotion.