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目的:观察二十五味珊瑚丸对致痫大鼠行为学和脑电的影响,评价二十五味珊瑚丸的抗痫效果。方法:将65只大鼠随机分5组,即模型组、珊瑚丸低、中和高剂量组(100mg/kg、200mg/kg、400mg/kg)和丙戊酸钠组,模型组大鼠在造模前灌胃给予去离子水,其他各组分别灌胃给药,连续干预7天,末次灌胃1h后,各组大鼠腹腔注射戊四氮,观察其行为学改变,描记脑电图变化。结果:珊瑚丸中、高剂量组及丙戊酸钠组大鼠发作性阵挛潜伏期、痫性发作级别、发作时间、阵挛次数和发作后恢复探索时间明显优于模型组。模型组大鼠阵发出现大量高幅尖波、棘波、棘慢复合波及尖慢综合波,珊瑚丸中、高剂量组和丙戊酸钠组只见极少量的棘波或尖波。结论:二十五味珊瑚丸可改善大鼠急性痫性发作行为的各项指标,抑制脑电痫样放电。
Objective: To observe the effect of twenty-five coral pills on the behavior and electroencephalogram of epileptic rats and evaluate the anti-epileptic effect of twenty-five coral pills. Methods: 65 rats were randomly divided into 5 groups: model group, low, medium and high coral pills group (100mg / kg, 200mg / kg, 400mg / kg) and sodium valproate group Before modeling, deionized water was given intragastrically. The other groups were intragastrically administrated with continuous intervention for 7 days. After the last intragastric administration for 1 hour, rats in each group were injected intraperitoneally with pentylenetetrazol. The behavioral changes were observed and EEG Variety. Results: Epileptic climacteric latency, epileptic seizure level, seizure time, the number of seizures and recovery time after seizure were significantly higher in Coral Pills medium, high dose and sodium valproate groups than in model group. In the model group, a large number of spikes and spikes were observed in the rat paroxysm. The combination of spikes and spikes was slow and complex, while the spike waves or spikes were observed in the Coral Pills medium, high dose and sodium valproate groups. Conclusion: Twenty-five coral pills can improve the indexes of acute seizure in rats and inhibit the discharge of electroencephalogram.