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用乌拉坦麻醉、骨骼肌麻痹的豚鼠实验。氯苯甲噻嗪(Dlazoxide)(10,20或40mg/Kg)可使动物气流阻力(R_L)明显增加和肺动态顺应性(C_L)明显减少,这种变化与用药剂量相关。注射药物10～20秒钟后出现作用,1～2分内达到最高峰,然后经过5～10分钟降至对照水平。与此相反,氨茶碱(30mg/Kg)和异丙肾上腺素(0.07μg/Kg)均不能使R_L或C_L产生明显变化。预先给予阿托品(0.05mg/Kg)的动物对氯苯甲噻
Guinea pigs anesthetized with urethane and paralyzed by skeletal muscle. Dlazoxide (10, 20 or 40 mg / Kg) significantly increased the animal’s airflow resistance (R_L) and pulmonary dynamic compliance (C_L), which was related to the dosage of Dlazoxide. Injection of drugs after 10 to 20 seconds to play a role, reached the peak within 1 to 2 minutes, and then dropped to the control level after 5 to 10 minutes. In contrast, neither aminophylline (30 mg / Kg) nor isoproterenol (0.07 μg / Kg) produced a significant change in R_L or C_L. The animals were given atropine (0.05 mg / Kg) of p-chlorothiazide