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We assessed the role of diabetes mellitus(DM) on treatment effects in drug‐susceptible initial pulmonary tuberculosis(PTB) patients. A prospective study was conducted in eight provinces of China from October 2008 to December 2010. We enrolled 1,313 confirmed drug‐susceptible initial PTB patients, and all subjects received the treatment regimen(2 H3 R3 E3 Z3/4 H3 R3) as recommended by the national guidelines. Of the 1,313 PTB patients, 157(11.9%) had DM; these patients had more sputum smear‐positive rates at the end of the second month [adjusted odds ratios(aO R) 2.829, 95% confidence intervals(CI) 1.783‐4.490], and higher treatment failure(aO R 2.120, 95% CI 1.565‐3.477) and death rates(aO R 1.536, 95% CI 1.011‐2.628). DM was a contributing factor for culture‐positive rates at the end of the second month and treatment failure and death of PTB patients, thus playing an unfavorable role in treatment effects of PTB.
We assessed the role of diabetes mellitus (DM) on treatment effects in drug-susceptible initial pulmonary tuberculosis (PTB) patients. A prospective study conducted in eight provinces of China from October 2008 to December 2010. We enrolled 1,313 confirmed drug-susceptible initial Of the 1,313 PTB patients, 157 (11.9%) had DM; these patients had more sputum smear-positive (2 H3 R3 E3 Z3 / 4 H3 R3) as recommended by the national guidelines. rates at the end of the second month [adjusted odds ratios (aO R) 2.829, 95% confidence intervals (CI) 1.783-4.490], and higher treatment failure (aO R 2.120, 95% CI 1.565-3.477) and death rates aO R 1.536, 95% CI 1.011-2.628). DM was a contributing factor for culture-positive rates at the end of the second month and treatment failure and death of PTB patients, playing an unfavorable role in treatment effects of PTB.