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目的回顾性分析采用改良长方案和经典长方案控制性超促排卵的不孕症患者妊娠结局,以评估改良长方案对体外受精-胚胎移植患者的累计妊娠率和活产率的影响。方法收集我院2008年-2012年因输卵管盆腔因素行体外受精-胚胎移植患者的病例资料,根据促排卵方案分为改良长方案(931例)与经典长方案(370例)两组,比较两组患者的累计妊娠率和活产率。结果 1.改良长方案组新鲜周期活产率(54.84%)明显高于经典长方案组(33.03%),有显著统计学意义(P<0.001)。2.上述患者中共有348例改良长方案和179例经典长方案行解冻复苏移植周期,改良长方案组活产率(48.28%)高于经典长方案组(32.40%),有显著统计学意义(P<0.001)。3.改良长方案组周期累计妊娠率(74.86%)与经典长方案组比较,(70.27%)无统计学差异(P=0.334),但改良长方案组累计活产率(63.05%)高于经典长方案组(44.86%),有显著统计学意义(P<0.001)。结论改良长方案不能增加患者的周期妊娠率,但可以提高患者的周期活产率。
Objective To retrospectively analyze the pregnancy outcomes of infertile patients with modified long-term regimen and classical long-term controlled ovariectomized ovulation induction (OVA) to evaluate the impact of the modified long-term regimen on cumulative pregnancy rate and live birth rate in patients undergoing in vitro fertilization-embryo transfer. Methods The data of patients undergoing IVF-ET in our hospital from 2008 to 2012 were collected and divided into two groups according to ovulation induction program: modified long protocol (931 cases) and classic long protocol (370 cases) Group of patients with cumulative pregnancy rate and live birth rate. The results showed that the live cycle rate (54.84%) in the modified long-term regimen group was significantly higher than that in the classical long-term regimen group (33.03%), with significant statistical significance (P <0.001). There were 348 cases of modified long-term plan and 179 cases of classic long-term plan of thawed and revived transplantation in the above patients. The live birth rate (48.28%) in the modified long-term plan group was higher than that of the classic long-term plan group (32.40%), with significant statistical significance (P <0.001). The cumulative pregnancy rate in the long-term regimen group (74.86%) was not significantly different from that in the long-term regimen group (70.27%) (P = 0.334), but the cumulative live birth rate in the long regimen group (63.05% The classic long-term treatment group (44.86%) was statistically significant (P <0.001). Conclusion The modified long program can not increase the cycle pregnancy rate of patients, but can improve the cycle of live births.