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概述 1984年间在肿瘤生物学方面取得了很大进展。首先,阐明了致癌基因在致癌过程中所起的作用,并在某些特定的肿瘤病因学方面取得的进展。论述了生长因子在癌基因的表达和控制中的作用,以及基因增殖作用是耐药性的一种机理。较详细地报道了抗肿瘤药物的耐药性问题。有许多综述涉及了二氢叶酸还原酶(DHFR)抑制剂的构效关系和叶酸拈抗剂的
Summary 1984 made great progress in oncology. First, elucidate the role of oncogenes in carcinogenesis and the progress made in some specific oncological etiologies. The role of growth factors in the expression and control of oncogenes and the mechanism of gene proliferation as a drug resistance are discussed. Drug resistance of antitumor drugs is reported in more detail. There are many reviews that deal with the structure-activity relationship of dihydrofolate reductase (DHFR) inhibitors and the folic acid antagonist