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目的:探讨孟鲁司特钠辅用玉屏风颗粒治疗儿童咳嗽变异性哮喘的临床疗效。方法:采用随机、平行对照研究方法,将180例患儿随机分为3组,均予常规治疗,A组58例给予布地奈德气雾剂,B组62例给予孟鲁司特钠口服,C组60例给予孟鲁司特钠和玉屏风颗粒口服。均连续用药8周,随访6个月。结果:3组患儿治疗后临床症状缓解时间、治疗前后IgE和T细胞亚群变化、治疗前后肺功能变化以及复发情况都有统计学差异(P<0.05)或非常统计学差异(P<0.01),C组疗效较佳。结论:孟鲁司特钠联合用玉屏风颗粒治疗儿童咳嗽变异性哮喘有很好的疗效,且不良反应轻微,具有较好的临床价值。
Objective: To investigate the clinical efficacy of montelukast sodium with Yupingfeng granule in treating children with cough variant asthma. Methods: A randomized, parallel-controlled study was conducted in 180 children. All children were randomly divided into three groups. All patients were given conventional treatment. A group of 58 patients received budesonide aerosol, and B group of 62 patients received montelukast sodium orally, C group 60 patients given montelukast sodium and Yupingfeng particles oral. All patients were continuously treated for 8 weeks and followed up for 6 months. Results: There was significant difference (P <0.05) or significant difference (P <0.01) in the clinical symptom relief time, changes of IgE and T cell subsets before and after treatment, lung function changes and recurrence before and after treatment ), C group better efficacy. CONCLUSION: Montelukast combined with Yupingfeng granule has a good curative effect on cough variant asthma in children, with mild side effects and good clinical value.