围产期缺血性脑卒中是导致儿童期脑瘫的主要原因之一。美国国立卫生研究院将围产期缺血性脑卒中定义为:孕20周到出生后28 d内,继发于脑动脉或脑静脉的血栓形成或栓塞导致局部脑血流中断,通过神经影像学或神经病理学研究证实的一组异质性疾病(heterogeneous conditions)[1]。由于多数围产期缺血性脑卒中患儿在胎儿期和新生儿期无特异的临床表现,通常在一些常规检查中偶然发现,或者在脑卒中发生4~5个月后,出现 Perinatal ischemic stroke is one of the major causes of cerebral palsy in childhood. The National Institutes of Health defines perinatal ischemic stroke as a thrombosis secondary to cerebral arteries or cerebral veins within 20 weeks of gestation or 28 days after birth leading to a breakdown of regional cerebral blood flow through neuroimaging Or a group of heterogeneous conditions confirmed by neuropathological studies [1]. Since most children with perinatal ischemic stroke have no specific clinical manifestations during fetal and neonatal periods, they are usually found incidentally in some routine tests or 4-5 months after stroke