抗体,作为最早发现的免疫物质,一直是免疫学研究的中心课题.虽然对于抗体本身,在分子水平和基因水平上,都已有了比较充分的了解,但是,对于抗体产生的细胞水平,即B细胞(BC)如何被刺激物激活而成为抗体产生细胞这一基本过程,却仍未完全认识.按照克隆选择学说,抗原与BC膜免疫球蛋白(mIg)受体的反应导致了BC的增殖、成熟并分泌抗体.但是,以后的事实证明,问题远非如此简单.第一,仅仅抗原与mIg受体的反应并不足以诱导抗体 Antibodies, as the earliest discovered immunological substance, have always been the centerpiece of immunological research.Although the antibodies themselves have been well understood both at the molecular and genetic level, however, the level of antibodies produced at the cellular level The basic process by which B cells (BCs) are stimulated by stimuli to become antibody-producing cells is not yet fully understood. The reaction of antigens with BC membrane immunoglobulin (mIg) receptors, according to the theory of clonal selection, leads to the proliferation of BC , Maturation and secretion of antibodies.However, the subsequent facts prove that the problem is far from so simple.First, only the reaction of antigen and mIg receptor is not enough to induce antibodies