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目的:探讨不同幽门螺杆菌(Hp)感染程度对冠心病患者血脂代谢与炎性因子的影响情况。方法:选取2008年7月至2010年12月本院心内科收治的140例冠心病患者,均开展14C-尿素呼气试验,其中94例Hp感染阳性患者为观察组,38例Hp感染阴性患者为对照组,观察组患者依据感染程度划分为轻度组(71例)与重度组(23例)。依次对患者开展胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)等血脂指标以及高敏C反应蛋白(hs-CRP)与热休克蛋白60(HSP60)炎性因子检测,经统计学处理进行临床分析。结果:对照组、轻度感染组与重度感染组患者的TC、TG、LDL-C、hs-CRP与HSP60水平比较均具有统计学差异(P<0.05),并且呈现递增趋势。结论:Hp感染会加重影响冠心病患者的脂代谢异常与炎症反应,对心血管事件的发生具有促进作用。
Objective: To investigate the effects of different Helicobacter pylori (Hp) infection on blood lipid metabolism and inflammatory factors in patients with coronary heart disease. Methods: From July 2008 to December 2010, 140 patients with coronary heart disease admitted to our hospital were enrolled in the 14 C-urea breath test. Among them, 94 patients were positive for Hp infection and 38 patients were negative for Hp infection The patients in the observation group were divided into mild group (n = 71) and severe group (n = 23) according to the degree of infection. The patients were followed up for cholesterol, triglyceride, HDL-C, LDL-C and other blood lipid indicators and high-sensitivity C-reactive protein (hs-CRP) Shock Protein 60 (HSP60) inflammatory cytokines were detected and statistically analyzed for clinical analysis. Results: The levels of TC, TG, LDL-C, hs-CRP and HSP60 in control group, mild infection group and severe infection group were significantly different (P <0.05), and showed an increasing trend. Conclusion: Hp infection will aggravate the abnormal lipid metabolism and inflammatory response in patients with coronary heart disease, which may promote the occurrence of cardiovascular events.