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目的建立深圳地区正常妊娠妇女早、中、晚孕期的游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)参考区间。方法应用化学发光法对154名早孕、217名中孕、132名晚孕的健康孕妇进行甲状腺功能三项检测,建立不同孕期甲状腺功能三项指标的正常参考区间。结果早、中、晚孕期孕妇甲状腺功能三项参考区间均较正常非孕人群低,并且不同地区孕妇的参考区间亦有差别。结论建立地区及妊娠特异性甲状腺功能指标参考区间是非常必要的。
Objective To establish a reference interval of free triiodothyronine (FT3), free thyroxine (FT4) and thyrotropin (TSH) in normal pregnant women in early pregnancy, middle and late pregnancy in Shenzhen. Methods Thirty-four healthy pregnant women with early pregnancies, 217 middle-pregnant women and 132 late pregnant women underwent chemiluminescence. Thyroid function tests were performed to establish the normal reference interval of thyroid function in different pregnancy. Results Early, middle and late pregnancy thyroid function of the three reference intervals were lower than normal non-pregnant population, and pregnant women in different regions have different reference intervals. Conclusion It is necessary to establish regional and pregnancy-specific thyroid function index reference interval.