论文部分内容阅读
目的:确定氟罗沙星注射液临床应用的安全性。方法:对氟罗沙星注射液进行急性毒性试验、体外溶血试验、血管刺激试验。结果:小鼠静脉注射和腹腔注射的最大耐受量皆为100mg·kg~(-1),为人用剂量(6.67mg·kg~(-1))的14.99倍;60min溶血率低于5％;氟罗沙星注射液连续给药3天,给药部位未见异常,病理检查局部血管无明显异常。结论:氟罗沙星注射液具有较好的血液相容性,无血管刺激性且毒性较低。
Objective: To determine the safety of fleroxacin injection in clinical application. Methods: The acute toxicity test of fleroxacin injection, in vitro hemolysis test and blood vessel stimulation test. Results: The maximum tolerated dose of intravenous injection and intraperitoneal injection in mice was 100 mg · kg ~ (-1), which was 14.99 times of the human dose (6.67 mg · kg ~ (-1)). The hemolysis rate was lower than 5% ; Fleroxacin injection for 3 consecutive days, no abnormalities at the site of administration, pathological examination of local blood vessels without obvious abnormalities. Conclusion: Fleroxacin injection has good blood compatibility, no vascular irritation and low toxicity.