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植物中萜类化合物的抗肿瘤活性,近来引起了国内外的重视。1967年 Hartwell 报导了有50种以上的倍半萜对多种肿瘤模型有抑制作用。1977年 Cordell 等报导了新分到的一些具有抗肿瘤活性或细胞毒的新倍半萜内酯,大多数对 KB 细胞、P388白血病细胞人体喉上皮样癌显示活性,少数化合物对大白鼠 Walker56,小鼠白血病 L-1210有活性。我国进行的雷公藤及冬凌草等抗肿瘤的研究,其中活性成分均为萜类化合物。1976年我院开始了萜类植物成分的抗肿瘤活性的广筛工作,经药理试验,发现我国引种
The anti-tumor activity of terpenoids in plants has recently attracted attention at home and abroad. In 1967, Hartwell reported that more than 50 sesquiterpenes have inhibitory effects on multiple tumor models. In 1977, Cordell et al. reported on some new sesquiterpene lactones with antitumor activity or cytotoxicity. Most of them showed activity against KB cells and human leukocarcinoid carcinomas of P388 leukemia cells. A few compounds against the rat Walker56. Mouse leukemia L-1210 is active. The anti-tumor studies of Tripterygium wilfordii and Rabdosia rubescens carried out in China, in which the active ingredients are terpenoids. In 1976, our hospital began the screening work of the anti-tumor activity of terpenoid components. Through pharmacological experiments, we found that our country introduced