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用氨基甲酸乙酯腹腔麻醉SD大鼠,以膈肌放电和气管内压作为呼吸的指标。静脉注射吗啡(4mg/kg)能显著地抑制呼吸,表现为呼吸频率降低,膈肌放电积分幅度和每分膈肌电活动减少。预先向面神经后核内地区(mNRF)注射1μg/μl纳络酮0.5μl可大部分阻断静脉注射吗啡引起的呼吸抑制。向双侧mNRF微量注射0.5μl吗啡(10μg/μl)能引起呼吸暂停。如预先注射纳络酮(0.5μg)于双侧mNRF,可完全阻断mNRF注射吗啡引起的呼吸抑制。结果提示:mNRF存在吗啡受体,并在由静脉注射吗啡引起的呼吸抑制中起重要作用。
Sprague-Dawley rats were anesthetized with urethane, and diaphragmatic discharge and endotracheal pressure were used as indexes of respiration. Intravenous morphine (4mg / kg) can significantly inhibit the respiration, manifested as decreased respiratory rate, diaphragm discharge amplitude and per diaphragm electrophysiological activity decreased. Injecting 1 μg / μl naloxone 0.5 μl into the nucleus retrofacial region (mNRF) can largely block the respiratory depression induced by intravenous injection of morphine. Microinjection of 0.5 μl of morphine (10 μg / μl) into bilateral mNRF can cause apnea. Preincubation of naloxone (0.5 μg) on bilateral mNRF completely blocked the respiratory depression induced by mNRF injection of morphine. The results suggest that mNRF has morphine receptors and plays an important role in respiratory depression induced by intravenous morphine.