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笔者对颅脑损伤后下丘脑神经肽一类洋地黄物质(EDLS)、心房利钠多肽(ANP)、垂体前叶激素一催乳素(PRL)、生长激素(GH)和促甲状腺素(TSH)含量变化进行了临床与动物实验研究,着重分析了这些神经肽、激素变化的特点、病理生理基础及测定的临床意义。一、临床资料67例中男51例,女16例;平均年龄38.7岁。所有患者均系伤后24小时内入院。入院时 GCS 评分:GCS>8分组51例,GCS≤8分组16例。行头颅 CT 扫描39例,发现颅内血肿23例。50例行腰穿,压力增高38例。18例行开颅血肿清除术,其余病例采取非手术治疗。治疗结果:恢复良好53例,死亡14例。患者入院后即取静脉血6ml,首次腰穿时取CSF 5ml,伤后24小时、7天再次取血、CSF;对照组血标本来源于本院血库健
After the brain injury traumatic brain injury neuropeptide a class of digitalis substance (EDLS), atrial natriuretic peptide (ANP), anterior pituitary hormone prolactin (PRL), growth hormone (GH) and thyroid stimulating hormone (TSH) Content changes in clinical and animal experiments, focusing on the analysis of these neuropeptides, the characteristics of hormone changes, the pathophysiology and clinical significance of the determination. First, clinical data 67 cases of male 51 cases, 16 females; average age 38.7 years old. All patients were admitted within 24 hours after injury. Admission GCS score: GCS> 8 group 51 cases, GCS≤8 group 16 cases. Line cranial CT scan in 39 cases, found 23 cases of intracranial hematoma. 50 routine lumbar puncture, increased pressure in 38 cases. 18 cases of craniotomy hematoma, the remaining cases to take non-surgical treatment. Treatment outcome: 53 cases recovered well and 14 died. Patients admitted to the venous blood 6ml, CSF for the first time to take lumbar lumbar puncture, 24 hours after injury, 7 days again to take blood, CSF; control group blood samples from the hospital blood bank health