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目的:探讨大鼠心肺复苏后早期心型脂肪酸结合蛋白的变化情况。方法:30只雄性SD大鼠,经食道快速起搏心室诱发室颤、建立心脏骤停模型,起搏开始后5 min立即开始胸外心脏按压及机械通气,按压1min时经股静脉注射肾上腺素0.02 mg/kg,观察自主循环恢复情况,10 min无效则放弃复苏。分为假手术组、复苏失败组、复苏后0.5 h、1 h、2 h、4 h组,各组5只。各时间点检测大鼠血心型脂肪酸结合蛋白。结果:各组大鼠基础状态各项参数无显著性差异,复苏组自主循环恢复时间无显著性差异。复苏后0.5 h组大鼠脂肪酸结合蛋白明显高于假手术组(P<0.05)。之后呈下降趋势,4 h组再次升高。结论:大鼠在心肺复苏后早期脂肪酸结合蛋白升高,且呈双峰趋势,其具体机制还有待于进一步研究。
Objective: To investigate the changes of early heart-type fatty acid-binding protein after cardiopulmonary resuscitation in rats. Methods: Thirty male Sprague Dawley rats were induced by rapid pacing ventricular fibrillation. Cardiac arrest was established. Cardiac arrest and mechanical ventilation were started immediately 5 min after pacing onset. Adrenaline 0.02 mg / kg, observe the recovery of spontaneous circulation, 10 min is invalid, then give up the recovery. The rats were divided into sham operation group, failure recovery group, 0.5 h, 1 h, 2 h and 4 h after resuscitation, and 5 rats in each group. Rats at each time point to detect blood type heart fatty acid binding protein. Results: There was no significant difference in the parameters of basal state in each group, and there was no significant difference in the recovery time of spontaneous circulation in resuscitation group. At 0.5 h after resuscitation, the fatty acid binding protein in rats was significantly higher than that in sham operation group (P <0.05). After a downward trend, 4 h group increased again. CONCLUSION: The content of fatty acid-binding protein in early stage after cardiopulmonary resuscitation in rats is high and shows a bimodal trend. The specific mechanism remains to be further studied.