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目的探讨nesfatin-1与2型糖尿病共病抑郁症的相关性。方法选取2型糖尿病(T2DM)患者77例,根据抑郁症诊断标准分为T2DM共病抑郁症组25例(DDM组)、T2DM非抑郁症组52例(NDDM组);以年龄、性别相匹配的30例健康体检者为正常对照组(NC组)。用汉密尔顿抑郁量表(HAMD)测量,并检测血浆nesfatin-1、空腹血糖(FPG)、血脂、空腹胰岛素(FINS)等水平。比较三组nesfatin-1水平变化,分析其与HAMD分数及其他指标的相关性。结果 DDM组nesfatin-1水平明显高于NDDM组及NC组(P<0.01)。T2DM患者(77例)nesfatin-1水平与HAMD分数、C肽、甘油三酯(TG)呈显著正相关(P<0.05)。回归分析示HAMD分数、TG和低密度脂蛋白-胆固醇(LDL-C)是影响nesfatin-1水平的独立相关因素(P<0.05);nesfatin-1与DDM密切相关(OR=1.140,P<0.01)。结论共病抑郁症的T2DM患者血浆nesfatin-1水平较非抑郁症组显著升高,其与T2DM患者的抑郁程度相关,其改变可能在DDM发生发展中发挥一定作用。
Objective To investigate the relationship between nesfatin-1 and comorbid depression in type 2 diabetes mellitus. Methods Twenty-seven patients with type 2 diabetes mellitus (T2DM) were divided into 25 groups (DDM group) and 52 non-depressive group (NDDM group) according to the diagnostic criteria of depression. Age and sex matched 30 healthy subjects were normal control group (NC group). The levels of plasma nesfatin-1, fasting blood glucose (FPG), lipids and fasting insulin (FINS) were measured by Hamilton Depression Rating Scale (HAMD). The levels of nesfatin-1 in three groups were compared, and their correlations with HAMD scores and other indexes were analyzed. Results The nesfatin-1 level in DDM group was significantly higher than that in NDDM group and NC group (P <0.01). The level of nesfatin-1 in T2DM patients (77 cases) was positively correlated with HAMD score, C-peptide and triglyceride (TG) (P <0.05). Regression analysis showed that HAMD score, TG and LDL-C were independent risk factors for nesfatin-1 (P <0.05); nesfatin-1 was closely related to DDM (OR = 1.140, P <0.01) ). Conclusions The plasma level of nesfatin-1 in T2DM patients with comorbid depression is significantly higher than that in non-depressed patients, which is correlated with the degree of depression in patients with T2DM. The changes may play a role in the occurrence and development of DDM.