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目的探讨胃肠道间质瘤(GIST)的组织学特点以及免疫组化标记在诊断与鉴别诊断中的意义。方法对25例GIST进行光镜观察,用免疫组化方法检测CD117(c-kit)、CD34、SMA、S-100抗原标记物在肿瘤中的表达情况。探讨GIST的良恶性判断标准。结果 25例中良性15例,潜在恶性6例,恶性4例;GIST由梭形细胞、上皮样细胞构成;CD117和CD34在GIST的阳性率较高,分别为92%、80%,个别病例SMA和(或)S-100呈点灶状阳性。结论 CD117、CD34、SMA以及S-100有助于GIST的诊断,GIST的诊断与鉴别诊断需结合组织学特点和免疫组化结果综合判断。
Objective To investigate the histological features of gastrointestinal stromal tumors (GISTs) and the significance of immunohistochemical markers in the diagnosis and differential diagnosis. Methods 25 cases of GIST were observed by light microscopy. The expression of CD117 (c-kit), CD34, SMA and S-100 antigen in the tumor was detected by immunohistochemistry. To investigate the benign and malignant judgment of GIST. Results Among the 25 cases, 15 cases were benign, 6 cases were potentially malignant and 4 cases were malignant. GIST was composed of spindle cells and epithelioid cells. The positive rates of CD117 and CD34 in GIST were 92% and 80% And (or) S-100 was focal spot-like positive. Conclusion CD117, CD34, SMA and S-100 contribute to the diagnosis of GIST. The diagnosis and differential diagnosis of GIST need to be combined with histological features and immunohistochemical findings.