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阿齐霉素为含氮大环内酯类抗生素,结构与大环内酯类相似,但生物学特性却截然不同。阿齐霉素对酸稳定,半衰期长,感染部位组织及细胞内浓度高,疗效显著,安全性和耐受性好。 药理作用 阿齐霉素通过与核糖体50S亚基结合,阻断肽移位,阻止细菌多肽合成而发挥抗菌作用。对革兰氏阳性需氧菌比红霉素稍差,对革兰氏阴性菌抗菌谱广、作用强,对流感嗜血杆菌、百日咳杆菌、杜
Azithromycin is a nitrogen-containing macrolide antibiotic with a similar structure as macrolides, but with distinct biological properties. Azithromycin is stable to acid, has a long half-life, high levels of tissue and intracellular concentrations at the site of infection, has significant efficacy, and is safe and well tolerated. Pharmacological effects Azithromycin binds to the 50S subunit of ribosomes to block peptide translocation and prevent bacterial polypeptide synthesis and exert antimicrobial activity. Gram-positive aerobic bacteria slightly worse than erythromycin, Gram-negative bacteria wide antibacterial spectrum, the role of strong, against Haemophilus influenzae, Bordetella pertussis, Du