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目的:探讨使用滴定表能否提高ST段抬高型心肌梗死(STEMI)患者院内美托洛尔剂量。方法:纳入STEMI患者100例,随机分配至滴定组(50例)与对照组(50例),比较两组患者入院24h内美托洛尔治疗率及出院前美托洛尔剂量的差异,观察6个月内主要心血管不良事件(MACE)发生率。结果:24h内美托洛尔治疗率无统计学差异(84%︰82%)。滴定组出院前高剂量组(30例)占比高于对照组(8例)(60%︰16%,P=0.000),滴定组目标剂量组(6例)占比高于对照组(12%︰0%,P=0.027)。滴定组6个月内MACE发生率较对照组低,但无统计学差异(2%︰8%,P=0.362)。结论:滴定表的使用可以提高STEMI患者院内美托洛尔剂量,可能进一步改善STEMI患者的预后。
Objective: To investigate whether the use of titration tables can increase the propofol dose of propofol in patients with ST-elevation myocardial infarction (STEMI). Methods: One hundred patients with STEMI were randomly divided into titration group (50 cases) and control group (50 cases). The differences of metoprolol treatment and metoprolol dose before discharge between two groups were compared The incidence of major cardiovascular adverse events (MACE) within 6 months. Results: There was no significant difference in metoprolol treatment within 24h (84%: 82%). The proportion of high dose group (30 cases) in titration group was higher than that of control group (8 cases) (60%: 16%, P = 0.000), and the target dose group (6 cases) in titration group was higher than that of control group %: 0%, P = 0.027). The incidence of MACE within 6 months in the titration group was lower than that in the control group, but there was no significant difference (2%: 8%, P = 0.362). Conclusion: The use of titration table can increase the propofol dose of propofol in STEMI patients and may further improve the prognosis of STEMI patients.