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通过一组双盲法安慰剂对照随机取样试验,对阿糖腺甙治疗单纯疱疹病毒性脑炎的疗效进行了评价。阿糖腺甙每日剂量为15毫克/公斤,静脉滴注12小时,溶液浓度不超过0.7毫克/毫升。受试者共50例,28例从脑组织分离出Ⅰ型单纯疱疹病毒,其中18例阳性者用阿糖腺甙,10例阳性者作对照。用药组单纯疱疹病毒性脑炎的死亡率明显降低,从70％降为28％(P=0.03),治疗存活的病人50％以上没有或仅有轻度的神经后遗症。应用本药取得了上述疗效,而无急性药物毒性。实验室检查未见骨髓、肝,肾功能对本药的严重不良反应。血红蛋白、白细胞、血小板数和血清中胆红素、谷草转氨酶的平均值均与对照组无差异。
A series of double-blind placebo-controlled randomized trials evaluated the efficacy of glycoside in the treatment of herpes simplex virus encephalitis. Vaginal adenosine daily dose of 15 mg / kg, intravenous infusion of 12 hours, the concentration of the solution does not exceed 0.7 mg / ml. A total of 50 subjects, 28 cases isolated from brain tissue herpes simplex virus type I, of which 18 were positive with glucuriloside, 10 were positive controls. The mortality from herpes simplex encephalitis in the treatment group was significantly reduced from 70% to 28% (P = 0.03), and over 50% of the surviving patients had no or only mild neurological sequelae. The use of the drug achieved the above effect, but no acute drug toxicity. Laboratory tests showed no bone marrow, liver and kidney function serious adverse reactions to the drug. Hemoglobin, white blood cells, platelets and serum bilirubin, aspartate aminotransferase mean no difference with the control group.