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目的:研究免疫球蛋白(Ig)和补体(C)在口腔扁平苔藓(OLP)、盘状红斑狼疮(DLE)和慢性增殖型念珠菌病(CHC)中的表达,以期找出对口腔黏膜白色病变有辅助检查意义的更简便、有效的方法。方法:运用免疫组织化学非生物素二步法对OLP、DLE和CHC进行检测,并将结果进行统计学分析。结果:免疫组织化学染色显示免疫复合物在三组基底膜区和结缔组织中单核细胞的阳性表达率有统计学差异(P<0.05)。DLE组的基底膜区有免疫复合物的多元沉积。结论:运用免疫组织化学非生物素二步法检测Ig和C在口腔黏膜白色病变中的表达对其鉴别诊断有一定的辅助意义。
Objective: To study the expression of immunoglobulin (Ig) and complement (C) in oral lichen planus (OLP), discoid lupus erythematosus (DLE) and chronic proliferative candidiasis (CHC) Lesions have a more convenient and effective way to aid the examination. Methods: OLP, DLE and CHC were detected by immunohistochemical non-biotin two-step method and the results were statistically analyzed. Results: Immunohistochemical staining showed that there was a significant difference (P <0.05) in the positive expression rate of monocytes among three groups of basement membrane area and connective tissue. The basement membrane area of the DLE group has multiple deposits of immune complexes. Conclusion: The immunohistochemical non-biotin two-step method for the detection of Ig and C expression in oral mucosal lesions of white on its differential diagnosis of some secondary significance.