Based on energy dissipation and structural control principle, a new structural configuration, called the megasub controlled structure (MSCS) with friction damped braces (FDBs), is first presented. Meanwhile, to calculate the damping coefficient in the slipping state a new analytical method is proposed. The damping characteristics of one-storey friction damped braced frame (FDBF) are investigated, and the influence of the structural parameters on the energy dissipation and the practical engineering design are discussed. The nonlinear dynamic equations and the analytical model of the MSCS with FDBs are established. Three building structures with different structural configurations, which were designed with reference to the conventional mega-sub structures such as used in Tokyo City Hall, are comparatively investigated. The results illustrate that the structure presented in the paper has excellent dynamic properties and satisfactory control effectiveness.