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目的：观察精氨酸在病理状态下对免疫功能的调节作用；方法：建立大鼠阻塞性黄疸模型，采用胸腺细胞及ＣｏｎＡ激活的脾细胞增殖法检测阻塞性黄疸大鼠ＩＬ－１及ＩＬ－２的活性；结果：阻塞性黄疸大鼠ＬＰＳ诱导的腹腔巨噬细胞产生的ＩＬ－１及Ｔ细胞分泌的ＩＬ－２均降低，精氨酸（２．７ｇ·ｋｇ－１·ｄ－１×７ｄ，ｉｇ）能使上述改变恢复正常，且精氨酸在该剂量对正常及阻塞性黄疸大鼠的肝肾功能无明显影响；结论：精氨酸对阻塞性黄疸大鼠免疫功能的降低有上调作用。
Objective: To observe the regulatory effect of arginine on immune function in pathological conditions.Methods: To establish a model of obstructive jaundice in rats and detect the expression of IL-1 and IL-10 in obstructive jaundice rats by using thymocyte and ConA-activated spleen cell proliferation assay. 2 activity of IL-1 and T cells secreted by LPS-induced peritoneal macrophages in obstructive jaundice rats were decreased. Arginine (2.7g · kg-1 · d-1 × 7d, ig) can make these changes returned to normal, and arginine in the dose of normal and obstructive jaundice had no significant effect on liver and kidney function; Conclusion: arginine on immune function in obstructive jaundice decreased Up effect