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1965年Pecile和Mtiller据实验推测下丘脑存在一种能抑制生长激素释放的物质。嗣后Krulich等指出这可能是一种肽类。直到1972年,Guillemin等才成功地从羊的下丘脑分离到并确定是一种十四肽。当时认为这是下丘脑分泌的特异性物质,故称为生长激素释放抑制因素(somatostatin,下称抑释生长素),以后的研究特别是应用免疫荧光技术证明,除下丘脑以及中枢神经系统、周围交感神经节等组织外,胃肠道亦存在这种激素,尤其是胰岛D细胞内,其作用也不只是抑制生长激素的释放。
1965 Pecile and Mtiller experimentally speculated that there is a substance that inhibits the release of growth hormone in the hypothalamus. Krulich later pointed out that this may be a kind of peptide. It was not until 1972 that Guillemin et al. Successfully isolated from the hypothalamus of the sheep and identified it as a tetradecapeptide. At that time, it was thought that this is a specific substance secreted by the hypothalamus, so called somatostatin (somatostatin, hereinafter referred to as inhibitor of growth hormone), later studies, especially the use of immunofluorescence technology to prove, in addition to the hypothalamus and central nervous system, Surrounding the sympathetic ganglia and other tissues, the gastrointestinal tract also exists in this hormone, especially in islet D cells, its role is not just inhibit the release of growth hormone.