论文部分内容阅读
目的探讨肾嫌色细胞癌的临床病理特征、免疫学表型、鉴别诊断及预后。方法对8例肾嫌色细胞癌进行光镜观察、免疫组织化学研究,分别随访5-75个月。结果大体肿块直径2.5-7.0cm。镜下,肿瘤由嫌色细胞和嗜酸细胞构成,呈片状、梁状和腺状分布。嫌色细胞体积较大、多角形,细胞膜清晰而厚,细胞质半透明细网状,细胞核皱缩,可见核沟及核异型,核仁不明显;而嗜酸细胞胞质嗜酸,可见明显的核周空晕。免疫表型EMA、CD117和E-cadherin 100%阳性,CD1050%阳性,CK7 75%阳性,P504S25%阳性,Vimentin 100%阴性。结论肾嫌色细胞癌是一种少见的肾脏肿瘤,预后好于肾透明细胞癌,与乳头状肾细胞癌相当。其特征性的组织学形态、免疫表型、电镜及遗传学改变有助于诊断和鉴别诊断。
Objective To investigate the clinicopathological features, immunological phenotype, differential diagnosis and prognosis of chromophobe renal cell carcinoma. Methods Eight cases of chromophobe renal cell carcinoma were observed by light microscopy and immunohistochemistry, and were followed up for 5-75 months. Results gross mass diameter 2.5-7.0cm. Microscope, the tumor by the chromophobe cells and eosinophils, flaky, beam-like and glandular distribution. Chromic cells larger, polygonal, clear and thick cell membrane, the cytoplasm of translucent fine mesh, the nucleus shrinkage, showing the nuclear ditch and nuclear atypia, nucleoli are not obvious; while the eosinophil cytoplasmic acid, visible Nuclear halo week halo. Immunophenotypes EMA, CD117 and E-cadherin were 100% positive, CD1050% positive, CK7 75% positive, P504S25% positive and Vimentin 100% negative. Conclusion Kidney chromophobe carcinoma is a rare renal tumor, the prognosis is better than that of clear cell renal cell carcinoma, and papillary renal cell carcinoma is quite. Its characteristic histological morphology, immunophenotype, electron microscopy and genetic changes contribute to the diagnosis and differential diagnosis.