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目的探讨布地奈德混悬液联合异丙托溴铵雾化治疗小儿支气管肺炎的效果。方法选择2012年3月—2014年3月收治的80例小儿支气管肺炎患儿作为研究对象,随机分为对照组和观察组各40例。对照组行常规治疗,观察组在对照组基础上行布地奈德混悬液联合异丙托溴铵雾化治疗。两组均治疗1周。分析两组患儿治疗后临床疗效及发热、气促、喘憋、咳嗽等主要症状缓解时间。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果观察组总有效率为92.50%,对照组为72.50%,差异有统计学意义(P<0.05)。观察组患儿发热消退时间、气促缓解时间、憋喘缓解时间、咳嗽消失时间分别为(3.02±1.21)、(2.35±1.36)、(2.31±1.28)、(4.11±1.52)d,显著优于对照组的(6.38±2.35)、(5.91±2.06)、(5.64±1.85)、(7.94±1.24)d,差异均有统计学意义(均P<0.05)。结论布地奈德混悬液联合异丙托溴铵雾化治疗小儿支气管肺炎效果显著,安全性高,可快速缓解症状,改善患儿体征,值得临床进一步推广使用。
Objective To investigate the effect of budesonide suspension combined with ipratropium bromide atomization on bronchial pneumonia in children. Methods Eighty children with bronchial pneumonia admitted from March 2012 to March 2014 were selected as study subjects and randomly divided into control group and observation group of 40 cases. The control group received routine treatment. The observation group was given budesonide suspension combined with ipratropium bromide atomization on the basis of the control group. Both groups were treated for 1 week. Analysis of two groups of children after treatment, clinical efficacy and fever, shortness of breath, wheezing, cough and other major symptoms of remission time. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate was 92.50% in observation group and 72.50% in control group, the difference was statistically significant (P <0.05). In the observation group, the subsided time of fever, the time of relieving shortness of breath, the time of relieving asthma and the disappearance of cough were (3.02 ± 1.21), (2.35 ± 1.36), (2.31 ± 1.28) and (4.11 ± 1.52) d respectively (6.38 ± 2.35), (5.91 ± 2.06), (5.64 ± 1.85) and (7.94 ± 1.24) d in the control group, all of which were statistically significant (all P <0.05). Conclusion Budesonide suspension combined with ipratropium bromide atomization treatment of bronchial pneumonia in children with significant effect, high security, can quickly relieve symptoms and improve the signs of children worth to further promote the use of the clinical.