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本文探讨了氟碳代血液(FCBS)对大鼠血液流变学的影响。Wistar大鼠20只,体重163～273g,从颈静脉以7.5ml/kg放血。随后实验组(n=9)输注与失血等量的FCBS,对照组输注乳化剂F-68(n=6)或生理盐水(n=5)。观察输注后30分钟其血液流变学的变化。结果显示:输注FCBS后30分钟,大鼠全血粘度明显降低,微血管血流速度明显加快,而对照组无明显变化;血球压积、红细胞聚集和微血管管径各组均无明显改变。输注FCBS和F-68后5分钟,微静脉内翻滚的白细胞减少,贴壁的白细胞增多,后者以F-68组更为明显,输注后15分钟已恢复到输注前水平。提示输注FCBS有改善血液流变学的效应,白细胞贴壁的增加可能与F-68有关。
This article explored the effects of fluorocarbon blood (FCBS) on hemorheology in rats. Twenty Wistar rats weighing 163-273 g were bled from the jugular vein at 7.5 ml / kg. Subsequently, the experimental group (n = 9) was infused with an equivalent amount of FCBS for blood loss and the control group was infused with emulsifier F-68 (n = 6) or saline (n = 5). Observed changes in hemorheology 30 minutes after infusion. The results showed that at 30 minutes after FCBS infusion, the viscosities of whole blood of rats decreased significantly and the velocity of capillary blood flow increased obviously, while there was no significant change in control group. No significant changes were observed in hematocrit, erythrocyte aggregation and microvessel diameter. Five minutes after infusion of FCBS and F-68, there was leukopenia and adherent leukocytosis in the CVT, which was more pronounced in the F-68 group and returned to pre-infusion levels 15 minutes after infusion. It is suggested that FCBS has the effect of improving hemorheology. The increase of adherent white blood cells may be related to F-68.