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目的 研究某些神经肽在中枢对大鼠胃粘膜血流量 (GMBF)的影响。方法 采用氢气清除法测定大鼠GMBF,分别向侧脑室内微量注射降钙素基因相关肽 (CGRP)、促胃液素 - 17(G1 7)、甲硫脑啡肽 (Met- enk)、铃蟾肽 (Bom )、神经肽 Y(NPY)和生长抑素 (SS)时 GMBF的变化。结果 1CGRP、G1 7均引起 GMBF的显著增加 ,其中 CGRP作用较强 ;NPY则降低 GMBF;而 Met- enk、Bom、SS对 GMBF无显著影响。 2一氧化氮 (NO)生物合成阻滞剂 L-硝基精氨酸甲基酯 (L- NAME)可完全阻断 CGRP引起的 GMBF增加效应 ,而对 G1 7所引起的效应仅部分阻断。结论 中枢 CGRP、G1 7、NPY对 GMBF有显著的调节作用 ,其中 CGRP、G1 7对 GMBF的增加效应与 NO有关
Objective To study the effect of certain neuropeptides on gastric mucosal blood flow (GMBF) in rats. Methods GMBF was measured by hydrogen scavenging in rats. Microinjection of calcitonin gene related peptide (CGRP), gastrin - 17 (G1 7), met-enkephalin (Met-enk) Peptide (Bom), Neuropeptide Y (NPY) and Somatostatin (SS). Results Both GGRF and G1GR induced a significant increase of GMBF, especially CGRP. NPY decreased GMBF, while Met-enk, Bom and SS had no significant effect on GMBF. 2 Nitric oxide (NO) biosynthesis blocker L-nitroarginine methyl ester (L-NAME) completely blocked the CGRP-induced increase in GMBF, whereas the effect caused by G1 7 was only partially blocked . Conclusion The central CGRP, G1 7, NPY have a significant regulatory effect on GMBF. The effect of CGRP and G1 7 on GMBF is related to NO