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对15例甲亢病人甲状腺进行病理和免疫组化的研究。病理切片观察为典型甲亢病理变化,免疫组化证实其中6例有淋巴滤泡,并在淋巴滤泡中可见为酶标记 IgG 着色的淋巴细胞。对国际标准品 LATS—B 和国内提取 LATS—天津两种甲状腺刺激自身抗体,进行一系列免疫学试验,实验结果证明 LATS—B 为 IgG 的多克隆免疫球蛋白,LATS—国内不是单一 IgG,尚含有 IgM。经 EL1SA 试验首次证实神经节苷脂Ⅱ、Ⅳ和Ⅴ型都能与上述两种 Tsaab 结合,且Ⅳ型与 LATS—B 结合较好。
Thyroid gland pathology and immunohistochemistry in 15 patients with hyperthyroidism. Histopathological examination showed pathological changes of typical hyperthyroidism. Immunohistochemistry confirmed that 6 of them had lymphoid follicles and lymphoid follicles showed enzyme-labeled IgG-stained lymphocytes. A series of immunological tests were carried out on the international standard LATS-B and the domestic LATS-Tianjin thyroid stimulating autoantibodies. The experimental results show that LATS-B is a polyclonal immunoglobulin of IgG, LATS-domestic is not a single IgG, Contains IgM. EL1SA test for the first time confirmed that gangliosides Ⅱ, Ⅳ and Ⅴ type can be combined with the above two Tsaab, and type Ⅳ and LATS-B is better.