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目的:观察低分子肝素对维持性血液透析患者凝血功能的影响。方法:将在我院血液净化中心行维持性血液透析治疗的53名患者,随机分成2组:普通肝素(unfractionated heparin,UFH)组和低分子肝素(lowmolecular weight heparin,LMWH)组,比较两组患者的出凝血时间,透析管路凝血情况和全身瘀斑、出血点的分布面积及持续时间。结果:LMWH组与UFH组相比,透析管路的凝血情况没有明显差异(P>0.05),但明显减轻了全身瘀斑,减少了出血点的分布面积及持续时间(P<0.05)。结论:低分子肝素在产生普通肝素同等抗血栓形成效果的同时,能明显减小维持性血液透析患者出血的危险性。
Objective: To observe the effect of low molecular weight heparin on the coagulation function of maintenance hemodialysis patients. Methods: Fifty-three patients undergoing maintenance hemodialysis in our hospital’s blood purification center were randomly divided into two groups: unfractionated heparin (UFH) group and low molecular weight heparin (LMWH) group. Out of patients with coagulation time, dialysis line coagulation and systemic ecchymosis, bleeding area and the distribution of the duration. Results: Compared with UFH group, there was no significant difference in blood coagulation between the LMWH group and the dialysis tubing (P> 0.05), but the systemic ecchymosis was significantly reduced and the distribution area and duration of the bleeding point were decreased (P <0.05). Conclusion: Low molecular weight heparin can produce the same anti-thrombotic effect of unfractionated heparin and reduce the risk of hemorrhage in maintenance hemodialysis patients.