论文部分内容阅读
目的:观测慢性肾功能衰竭(Chronic Renal Failure,CRF)肾功能、血浆丙二醛(MDA)、超氧化物歧化酶(SOD),以及心和小肠的超微结构尤其是线粒体形态的改变,研究线粒体与慢性肾衰尿毒素所致肾外脏器(心和小肠)损害相关性,并探讨CRF“尿毒症毒素致病学说”的深层机理。方法:采用5/6肾切除大鼠CRF模型,随机分为模型组、大黄治疗组、益肾降浊冲剂大、小剂量治疗组,并行假手术(不切除肾脏)作正常对照组,观察各组血肌酐(Scr)、尿素氮(BUN)、血浆MDA、SOD和心、小肠超微结构的改变。结果:(1)各组Scr、BUN、MDA值从大到小的顺序依次为:模型组、大黄组、益肾降浊冲剂大、小剂量组、正常对照组,SOD大小顺序与上述正好相反;各组之间均有统计学上显著性差异(P<0.01或P<0.05)。(2)CRF大鼠血浆MDA水平与BUN、Scr呈非常显著正相关(r=0.715,0.789,P<0.01,0.01),血浆SOD含量与BUN、Scr呈非常显著负相关(r=-0.719,-0.810,P<0.01,0.01)。(3)电镜观察心肌和小肠超微结构的改变与各组Scr、BUN、MDA相同,模型组的病变最重,细胞线粒体肿胀也最甚;大黄组病变次之;益肾降浊冲剂组的病变最轻,线粒体形态亦无明显改变。结论:尿毒症毒素通过影响线粒体功能而导致肾外脏器的组织细胞的损伤;而益肾降浊冲剂则通过减轻尿毒症毒素对全身各系统器官的功能细胞的线粒体损害从而在一定程度上保护了全身各系统。
OBJECTIVE: To observe the changes of renal function, plasma malondialdehyde (MDA), superoxide dismutase (SOD) and ultrastructure of heart and small intestine, especially mitochondrial morphology in Chronic Renal Failure (CRF) Mitochondria and chronic renal failure caused by uremia, renal extracorporeal organs (heart and small intestine) damage, and to explore CRF “uremic toxins pathogenic theory ” deep mechanism. Methods: The CRF model of 5/6 nephrectomized rats was randomly divided into model group, rhubarb treatment group, Yishenjianzhuo granule large and small dose treatment group, and sham operation (without removal of kidney) as normal control group. Serum creatinine (Scr), blood urea nitrogen (BUN), plasma MDA, SOD and heart, small intestine ultrastructure changes. Results: (1) The order of Scr, BUN and MDA in each group was as follows: model group, rhubarb group, Yishen Jiangzhu granules large and small dose group, normal control group, the order of SOD size was the opposite There was a statistically significant difference between groups (P <0.01 or P <0.05). (2) There was a significant positive correlation between plasma MDA levels and BUN and Scr in CRF rats (r = 0.715,0.789, P <0.01,0.01). There was a significant negative correlation between plasma SOD and BUN and Scr (r = -0.719, -0.810, P <0.01, 0.01). (3) The ultrastructural changes of myocardium and small intestine were observed by electron microscope. The changes of Scr, BUN and MDA were the same in all groups. The lesions in the model group were the most serious and the mitochondrial swelling was most serious. The lesions in the rhubarb group followed by the Yishen Jiangzhuo granules group Lightest lesions, mitochondrial morphology did not change significantly. Conclusion: Uremic toxins can damage mitochondria and lead to damage of tissue cells in external organs of the kidney. Yishen Jiangzhu granules can protect mitochondria from mitochondria of functional organs in various organs of the body by reducing uremic toxins The whole body of the system.