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目的研究慢性阻塞性肺疾病急性加重期(AECOPD)患者痰培养的病原菌分布特点及耐药性,为临床合理使用抗生素提供依据。方法回顾性分析武清区人民医院于2014年1月—2015年12月收治的AECOPD患者154例的痰培养及药敏试验结果。结果 AECOPD患者革兰阴性杆菌对抗生素的总体耐药率以亚胺培南/西司他汀最低。AECOPD患者革兰阳性球菌对常用抗生素的总体耐药率,以万古霉素、替考拉宁最低。结论 AECOPD患者病原菌感染以革兰阴性杆菌为主,病原菌有明显耐药现象,临床上应合理使用抗生素,防止耐药细菌的产生。为合理有效使用抗生素提供参考。
Objective To study the distribution characteristics and drug resistance of pathogens in sputum culture of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and to provide basis for clinical rational use of antibiotics. Methods The sputum culture and drug sensitivity test results of 154 patients with AECOPD admitted to Wuqing District People’s Hospital from January 2014 to December 2015 were retrospectively analyzed. Results The overall antibiotic resistance rate of Gram-negative bacilli in AECOPD patients was the lowest in imipenem / cilastatin. The overall resistance rates of Gram-positive cocci to commonly used antibiotics in AECOPD patients were vancomycin and teicoplanin. Conclusions The pathogens of AECOPD are mainly Gram-negative bacilli. The pathogens are obviously drug-resistant. Antibiotics should be used reasonably to prevent the emergence of drug-resistant bacteria. For reasonable and effective use of antibiotics provide a reference.